DEAF1 Antibody - N-terminal region: FITC (ARP39467_P050-FITC)
Product Specifications
Gene Name
Deformed epidermal autoregulatory factor 1 (Drosophila)
Gene Aliases
SPN, NUDR, VSVS, MRD24, ZMYND5, NEDHELS
Gene ID
10522
Swiss Prot
O75398
Accession Number
NP_066288
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Yeast
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human DEAF1
Target
DEAF1 down-regulates transcription of those genes by binding to sequence with multiple copies of TTC[CG]G present in their own promoter and that of the HNRPA2B1 gene. DEAF1 binds to the retinoic acid response element (RARE) AGGGTTCACCGAAAGTTCA. DEAF1 activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.
Partner Proteins
IRF7; IRF3; CREB1; PELI1; PELI2; HRSP12; GSK3B; GSK3A; CDKN2A; PPP1CC; PPP1CA; CDC37; AIMP2; TK1; RAD23B; PIN1; HRAS; FHL1; CDKN1A; ASCC2; INTS1; LMO4; DEAF1
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/mL
Homology
Cow: 83%; Dog: 93%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Yeast: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
59kDa
Shipping Conditions
Wet Ice
Protein Length
565
NCBI Gene Symbol
DEAF1
Protein Name
Deformed epidermal autoregulatory factor 1 homolog
Nucleotide Accession Number
NM_021008
Curated Selection
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