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SART3 Antibody - N-terminal region : HRP (ARP39128_T100-HRP)

Selected Variant

ARP39128_T100-HRP

Size: 100 µL

Product Specifications

Gene Name

Squamous cell carcinoma antigen recognized by T cells 3

Gene Aliases

P100, p110, DSAP1, TIP110, p110 (nrb), RP11-13G14

Gene ID

9733

Swiss Prot

Q15020-2

Accession Number

AAK69347

Host

Rabbit

Reactivity

Human, Rat, Dog, Guinea Pig, Horse, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human SART3

Target

SART3 is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. SART3 is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This protein is thought to be involved in the regulation of mRNA splicing.

Partner Proteins

APBB1; PRPF3; Usp15; AMOT; SF3B1; NUP160; LRPPRC; THRAP3; BCLAF1; VARS; UBC; SUMO2; RAB1A; NEFM; IARS; HIF1A; DSG2; DHX9; MEPCE; HIST2H2BE; HIST2H2AC; RNF2; BMI1; RUFY1; NRBP1; PSME4; AKAP2; COPS5; NUP50; POP7; ARHGEF10; PSMB3; PSMA5; PSMA3; POLR2H; CAST

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Sample Type

SART3 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Dog: 77%; Guinea Pig: 79%; Horse: 79%; Human: 100%; Pig: 86%; Rat: 79%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

40kDa

References & Citations

Liu, Y., (2002) J. Biol. Chem. 277 (26), 23854-23863

Shipping Conditions

Wet Ice

Protein Length

364

NCBI Gene Symbol

SART3

NCBI GB Accession Number

SART3

Host or Source

Rabbit

Protein Name

Squamous cell carcinoma antigen recognized by T-cells 3

Nucleotide Accession Number

NM_014706

Peptide Sequence

TSASEPEAESKAGPKADGEEDEVKAARTRRKVLSRAVAAATYKTMGPAWD

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