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KLF12 Antibody - N-terminal region : Biotin (ARP38927_P050-Biotin)

Product Specifications

Gene Name

Kruppel-like factor 12

Gene Aliases

AP2REP, AP-2rep, HSPC122

Gene ID

11278

Swiss Prot

Q9Y4X4

Accession Number

NP_009180

Host

Rabbit

Reactivity

Human, Dog, Guinea Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human KLF12

Target

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. KLF12 is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1.Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.

Partner Proteins

THAP1; CTBP1; APP; EHMT2

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

KLF12 is strongly supported by BioGPS gene expression data to be expressed in 721_B

Concentration

0.5 mg/ml

Homology

Dog: 100%; Guinea Pig: 93%; Human: 100%; Rabbit: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

44kDa

References & Citations

Suda, S., (2006) Biochem. Biophys. Res. Commun. 344 (1), 246-252

Shipping Conditions

Wet Ice

Protein Length

402

NCBI Gene Symbol

KLF12

NCBI GB Accession Number

KLF12

Host or Source

Rabbit

Protein Name

Krueppel-like factor 12

Nucleotide Accession Number

NM_007249

Peptide Sequence

NIHMKRKTIKNINTFENRMLMLDGMPAVRVKTELLESEQGSPNVHNYPDM

Frequently Asked Questions

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