SUPT16H Antibody - middle region : Biotin (ARP38921_P050-Biotin)

Product Specifications

Gene Name

Suppressor of Ty 16 homolog (S. cerevisiae)

Gene Aliases

CDC68, SPT16, FACTP140, SPT16/CDC68

Gene ID

11198

Swiss Prot

Q9Y5B9

Accession Number

NP_009123

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Horse, Pig, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human SUPT16H

Target

Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit, the latter of which is SUPT16H. Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit, the latter of which is the protein encoded by this gene. Sequence Note: The sequence AF152961.1 is a chimeric mRNA clone. Only the SUPT16H region was propagated into this RefSeq record. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

HIST1H2AB; UBC; SUMO2; ATRX; SUMO1; NEDD8; RNF20; PAF1; EED; RNF2; BMI1; rev; FTH1; QRICH1; SRPK2; ICAM1; CD81; IGSF8; PNKP; VCP; FMNL1; SSRP1; ESR1; CENPA; LEO1; RBM25; PRPF6; NCSTN; RTF1; ACIN1; PSIP1; USP39; PRPF8; SF3A1; SAP18; CTR9; DDX21; PRPF3; PRP

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

SUPT16H is supported by BioGPS gene expression data to be expressed in HEK293T

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Goat: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.