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ELL Antibody - N-terminal region : HRP (ARP38813_T100-HRP)

Product Specifications

Gene Name

Elongation factor RNA polymerase II

Gene Aliases

MEN, ELL1, PPP1R68, C19orf17

Gene ID

8178

Swiss Prot

P55199

Accession Number

NP_006523

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human ELL

Target

ELL was shown to encode a previously uncharacterized elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. Functionally, ELL resembles Elongin (SIII), a transcription elongation factor regulated by the product of the von Hippel-Lindau (VHL) tumor suppressor gene.

Partner Proteins

UBC; LOC100363176; SNF8; MCM2; Polr2e; Polr2l; Polr2h; Polr2d; Polr2a; Polr2c; Polr2i; Polr2b; Polr2j; Polr2g; Polr2f; EAF1; ICE2; AFF4; PPP1CA; ICE1; MED26; MLLT3; CDK9; TFPT; KMT2A; MLLT1; USPL1; EAF2; HNRNPU; TP53; ZHX1; SIRT2

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 86%; Guinea Pig: 92%; Human: 100%; Mouse: 92%; Rat: 92%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

68kDa

References & Citations

Wiederschain, D., (2003) Mol. Cell. Biol. 23 (12), 4230-4246

Shipping Conditions

Wet Ice

Product Datasheet

Anti-ELL (ARP38813_T100-HRP) antibody

Protein Length

621

NCBI Gene Symbol

ELL

NCBI GB Accession Number

ELL

Host or Source

Rabbit

Protein Name

RNA polymerase II elongation factor ELL

Nucleotide Accession Number

NM_006532

Peptide Sequence

GLSCGRVSDGSKVSVFHVKLTDSALRAFESYRARQDSVSLRPSIRFQGSQ

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