NR1H3 Antibody - C-terminal region : Biotin (ARP38670_P050-Biotin)
Product Specifications
Gene Name
Nuclear receptor subfamily 1, group H, member 3
Gene Aliases
LXRA, LXR-a, RLD-1
Gene ID
10062
Swiss Prot
Q13133
Accession Number
NP_005684
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human NR1H3
Target
Interaction of NR1H3 with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. NR1H3 are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. NR1H3 Plays an important role in the regulation of cholesterol homeostasis.
Partner Proteins
RXRG; RXRB; MDFI; SUV39H1; KDM1A; BARD1; MSTO1; HSP90AA1; PIAS1; APP; NR3C1; MYC; ZXDC; TMEM161A; ING3; NCOA6; NCOR1; KAT2B; EIF3I; NRIP1; NCOA3; SRC; RXRA; FOXO3; ACTN1; SS18L1; LZTR1; EDF1; RARA; NR0B2; SYT1; PPARA; SIRT1; UBC; CEP350
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
50kDa
References & Citations
Torra, I.P., (2008) Mol. Cell. Biol. 28 (8), 2626-2636
Shipping Conditions
Wet Ice
Protein Length
447
NCBI Gene Symbol
NR1H3
NCBI GB Accession Number
NR1H3
Host or Source
Rabbit
Protein Name
Oxysterols receptor LXR-alpha
Nucleotide Accession Number
NM_005693
Peptide Sequence
IHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWD
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