Rest Antibody - middle region : FITC (ARP38643_P050-FITC)
Product Specifications
Gene Name
RE1-silencing transcription factor
Gene Aliases
N, NRSF, REST4, D14Mgi1, AA407358, 2610008J04Rik
Gene ID
19712
Swiss Prot
Q8VIG1
Accession Number
NP_035393
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Target
Rest is a transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Rest restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Rest mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
Partner Proteins
L3mbtl2; Htt; Nanog; Sp3; Ewsr1; Nr0b1; Syt4; Calb1; Scn2a1; Bdnf; Ascl1
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 86%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
118kDa
Shipping Conditions
Wet Ice
Protein Length
1082
NCBI Gene Symbol
REST
NCBI GB Accession Number
Rest
Host or Source
Rabbit
Protein Name
RE1-silencing transcription factor
Nucleotide Accession Number
NM_011263
Peptide Sequence
ANMGMALTNDMYDLHELSKAELAAPQLIMLANVALTGEASGSCCDYLVGE
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