CIR Antibody - C-terminal region : HRP (ARP38523_P050-HRP)
Product Specifications
Gene Name
Corepressor interacting with RBPJ, 1
Gene Aliases
CIR
Gene ID
9541
Swiss Prot
Q86X95
Accession Number
NP_004873
Host
Rabbit
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human CIR
Target
CIR may modulate splice site selection during alternative splicing of pre-mRNAs. CIR regulates transcription and acts as corepressor for RBPSUH by recruiting RBPSUH to the Sin3-histone deacetylase complex (HDAC) . CIR is also required for RBPSUH-mediated repression of transcription.
Partner Proteins
CEP76; NEK6; U2AF1; SRSF2; SRSF1; RP9; HDAC2; SAP30; SNW1; TCEA1; NCOR2; RBPJ
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Human: 100%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
52kDa
References & Citations
Maita, H., (2005) Exp. Cell Res. 303 (2), 375-387
Shipping Conditions
Wet Ice
Protein Length
450
NCBI Gene Symbol
CIR1
NCBI GB Accession Number
CIR1
Host or Source
Rabbit
Protein Name
Corepressor interacting with RBPJ 1
Nucleotide Accession Number
NM_004882
Peptide Sequence
RSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYREHPG
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