ZFP36 Antibody - middle region : Biotin (ARP38304_P050-Biotin)

Product Specifications

Gene Name

Zinc finger protein 36, C3H type, homolog (mouse)

Gene Aliases

TTP, G0S24, GOS24, TIS11, NUP475, zfp-36, RNF162A

Gene ID

7538

Swiss Prot

P26651

Accession Number

NP_003398

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human ZFP36

Target

ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.

Partner Proteins

YWHAB; PPP2CA; DNAJB1; DCP1B; DHX36; PRR5L; XRN1; UBC; TRAF2; EXOSC6; UPF2; EXOSC8; YWHAQ; TNF; DCP2; EDC3; DCP1A; EDC4; CDK6; APP; LIN28A; SH3KBP1; PABPC1; NCL; MAP3K4; HSPA4; HDAC7; HDAC3; NFKB1; HOXC9; HDAC1; CCDC85B; MAPKAPK2; YWHAG; SFN; HMGB1; NUP21

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93%; Sheep: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.