HMGA1 Antibody - N-terminal region : Biotin (ARP38111_P050-Biotin)

Product Specifications

Gene Name

High mobility group AT-hook 1

Gene Aliases

HMG-R, HMGIY, HMGA1A

Gene ID

3159

Swiss Prot

Q5T6U8

Accession Number

NP_002122

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human HMGA1

Target

This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene.

Partner Proteins

NCOR2; UBE2I; PPARG; UBC; UPF2; HTT; OLA1; DNAJC8; PSIP1; METAP2; SYNCRIP; CWC27; HNRNPDL; EIF2S2; PCBP2; PCBP1; PA2G4; NPM1; NCL; HSPA1A; HNRNPL; HNRNPD; HNRNPAB; HNRNPA1; HMGB3; HMGB2; HMGB1; GTF2F2; XRCC6; CSNK2A1; RCC1; CDK1; APEX1; ANXA2; ANXA1; SSB

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

HMGA1 is strongly supported by BioGPS gene expression data to be expressed in HT1080

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.