Runx1 Antibody - N-terminal region : Biotin (ARP37877_P050-Biotin)

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Runx1 is essential for the development of normal hematopoiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Runx1 acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. It inhibits KAT6B-dependent transcriptional activation .

Kat6a; Ubc; Cbfb; Foxp3; Rbbp4; Gata1; Fli1; Phc1; Cdk6; Cbx3; Bmi1; Pml; Mbd3; Smad2; Prmt1; Hdac2; Hcfc1; Gata2; Hdac1; Wdr5; Mta1; Smarcd1; Pcgf5; Smarcc2; Pold3; Smarce1; Set; Mta2; Ash2l; Tal1; Smarcc1; Smarcb1; Smarca4; Sin3a; Rnf2; Ring1; Cbfa2t3

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.