TBX21 Antibody - C-terminal region : Biotin (ARP37251_T100-Biotin)
Selected Variant
ARP37251_T100-Biotin
Size: 100 µL
Product Specifications
Gene Name
T-box 21
Gene Aliases
TBT1, Tbet, Tbly, Tblym
Gene ID
57765
Swiss Prot
Q9JKD8
Accession Number
NP_062380
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Pig, Rabbit, Sheep
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of mouse TBX21
Target
TBX21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. It is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG) . Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.
Partner Proteins
Bcl6; Smarca4; Tlx3; Tead4; Pax9; Gsc; Gata3; Dlx1; Alx4; Rbpj; Stat1; Ifng; Tec; Itk; Txk
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Concentration
0.5 mg/ml
Homology
Cow: 86%; Dog: 86%; Human: 93%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 93%; Sheep: 86%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
58kDa
References & Citations
Hirata, T., et al., (2006) Development 133 (8), 1433-1443
Shipping Conditions
Wet Ice
Protein Length
530
NCBI Gene Symbol
TBX21
NCBI GB Accession Number
TBX21
Host or Source
Rabbit
Protein Name
T-box transcription factor TBX21
Nucleotide Accession Number
NM_019507
Peptide Sequence
MDPGLGSSEEQGSSPSLWPEVTSLQPESSDSGLGEGDTKRRRISPYPSSG
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