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APEX1 Antibody - N-terminal region : HRP (ARP37014_T100-HRP)

Selected Variant

ARP37014_T100-HRP

Size: 100 µL

Product Specifications

Gene Name

Apurinic/apyrimidinic endonuclease 1

Gene Aliases

HA, APE, Apex, HAP1, Ref-, Ref-1

Gene ID

11792

Swiss Prot

Q544Z7

Accession Number

NP_033817

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of mouse APEX1

Target

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells.

Partner Proteins

Pcna; Gadd45a; Eed; Mutyh; Plcb1; Hdac1; Sin3a; Hdac2

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 93%; Goat: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 93%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

35kDa

References & Citations

Izumi, T., et al., (2005) Proc. Natl. Acad. Sci. U.S.A. 102 (16), 5739-5743

Shipping Conditions

Wet Ice

Protein Length

317

NCBI Gene Symbol

APEX1

NCBI GB Accession Number

APEX1

Host or Source

Rabbit

Protein Name

Apurinic/apyrimidinic endonuclease 1 EMBL EDL20835.1

Nucleotide Accession Number

NM_009687

Peptide Sequence

ETKKSKGAAKKTEKEAAGEGPVLYEDPPDQKTSPSGKSATLKICSWNVDG

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