MDC1 Antibody - C-terminal region : HRP (ARP36798_P050-HRP)
Selected Variant
ARP36798_P050-HRP
Size: 100 µL
Product Specifications
Gene Name
Mediator of DNA-damage checkpoint 1
Gene Aliases
NFBD1
Gene ID
9656
Swiss Prot
Q14676
Accession Number
NP_055456
Host
Rabbit
Reactivity
Human, Dog, Guinea Pig
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human MDC1
Target
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Partner Proteins
RPA3; RPA2; RPA1; EED; TOPBP1; RNF8; UBC; LMNA; RAG1; CDC27; NCL; NBN; MRE11A; CSNK2A1; RAD50; CAPZB; CAPZA1; AUP1; ATP2A2; LOC729324; CHAMP1; HNRNPUL2; PGAM5; LSM12; ANAPC16; OSBPL8; DTX2; ZNF251; RBM17; FAM175A; LAS1L; LPCAT1; MYH14; SLC25A22; ZNF768; H
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Sample Type
MDC1 is strongly supported by BioGPS gene expression data to be expressed in HepG2
Concentration
0.5 mg/ml
Homology
Dog: 86%; Guinea Pig: 92%; Human: 100%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
227kDa
Shipping Conditions
Wet Ice
Protein Length
2089
NCBI Gene Symbol
MDC1
NCBI GB Accession Number
MDC1
Host or Source
Rabbit
Protein Name
Mediator of DNA damage checkpoint protein 1
Nucleotide Accession Number
NM_014641
Peptide Sequence
GKEEDVVTPKPGKRKRDQAEEEPNRIPSRSLRRTKLNQESTAPKVLFTGV
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