RUNX2 Antibody - middle region: FITC (ARP36679_T100-FITC)
Product Specifications
Gene Name
Runt-related transcription factor 2
Gene Aliases
CCD, AML3, CCD1, CLCD, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2aA, CBF-alpha-1
Gene ID
860
Swiss Prot
Q13950
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human RUNX2
Target
The RUNX2 gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis, acting as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD) .
Partner Proteins
HDAC7; HDAC6; TP53; UBC; RB1; PML; HIF1A; SMURF1; SMAD1; SMURF2; HIVEP3; WWP1; FHL2; UBTF; SUV39H1; HDAC1; STAT3; SMAD3; RBM14; SOX9; NR0B2; EP300; HDAC5; HDAC4; HDAC3; CREBBP; XRCC5; HES1; XRCC6; BMPR1A; KAT2B; TLE1; YAP1; KAT6B; TAF1A; AXIN1; SMAD6; MAP
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Concentration
0.5 mg/mL
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 80%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
64kDa
Shipping Conditions
Wet Ice
Protein Length
589
NCBI Gene Symbol
RUNX2
Protein Name
Runt-related transcription factor 2 Ensembl ENSP00000319087 EMBL CAI19641.1
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