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DHX58 Antibody - N-terminal region : HRP (ARP36500_P050-HRP)

Selected Variant

ARP36500_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

DEXH (Asp-Glu-X-His) box polypeptide 58

Gene Aliases

LGP2, RLR-3, D11LGP2, D11lgp2e

Gene ID

79132

Swiss Prot

Q96C10

Accession Number

NP_077024

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human DHX58

Target

DHX58 is the negative regulator of host innate immune defense against viruses. The repressor domain of DHX58 interacts with DDX58 and negatively regulates DDX58-mediated signaling. Binds dsRNA produced during viral replication, in particuliar HCV RNA. Bin

Partner Proteins

USP21; APP; UBD; NKRF; CDKN2AIP; AGO2; STAU2; DICER1; DHX30; XRN2; STAU1; EIF2AK2; EIF6; AP2B1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 91%; Rabbit: 93%; Rat: 93%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

76kDa

References & Citations

Komuro, A. (2006) J. Virol. 80 (24), 12332-12342

Shipping Conditions

Wet Ice

Protein Length

678

NCBI Gene Symbol

DHX58

NCBI GB Accession Number

DHX58

Host or Source

Rabbit

Protein Name

Probable ATP-dependent RNA helicase DHX58

Nucleotide Accession Number

NM_024119

Peptide Sequence

AYVAKRHLETVDGAKVVVLVNRVHLVTQHGEEFRRMLDGRWTVTTLSGDM

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