INTS6 Antibody - C-terminal region : HRP (ARP36404_P050-HRP)

Product Specifications

Gene Name

Integrator complex subunit 6

Gene Aliases

HDB, INT6, DBI-1, DDX26, DICE1, DDX26A, Notchl2

Gene ID

26512

Swiss Prot

A8MV98

Accession Number

NP_001035026

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human INTS6

Target

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. INTS6 is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH) . DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH) . Three transcript variants encoding two different isoforms have been found for this gene.

Partner Proteins

RPA3; RPA2; RPA1; BMI1; UBC; MCM7; INTS10; CTDP1; SHFM1; DDX26B; NAIF1; INTS4; VWA9; INTS5; NABP2; C7orf26; INTS3; ZNF687; INTS2; INTS12; INTS9; ASUN; INTS8; CPSF3L; INTS6; INTS1; INTS7; ZMYND8; ZNF592; PPP2R1B; PPP2R1A; PPP2CB; PPP2CA; PPP1CB; POLR2L; PO

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 93%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.