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DDX42 Antibody - N-terminal region : HRP (ARP36403_P050-HRP)

Selected Variant

ARP36403_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 42

Gene Aliases

RHELP, RNAHP, SF3B8, DDX42P, SF3b125

Gene ID

11325

Swiss Prot

Q86XP3

Accession Number

NP_031398

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human DDX42

Target

DDX42 is a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX42 is a ATP-dependent RNA helicase. DDX42 binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. It also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein.This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene.

Partner Proteins

FUS; UBC; SUMO1; EED; SHFM1; FBXO25; LMNA; PRPF19; U2SURP; SF3A1; SF3B4; SNRPC; ITGA4; DHX15; PIN4; KAL1; EPRS; APP; PHF20; NOSIP; RPL36; FOXJ3; TCERG1; SYNCRIP; RPS6KA4; SUMO3; ISG15; SIRT7; SF3A2; MEPCE; RUVBL2; RUVBL1; RECQL5; SF3B1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

103kDa

References & Citations

Will, C.L., et al., (2002) EMBO J. 21 (18), 4978-4988

Shipping Conditions

Wet Ice

Protein Length

938

NCBI Gene Symbol

DDX42

NCBI GB Accession Number

DDX42

Host or Source

Rabbit

Protein Name

ATP-dependent RNA helicase DDX42

Nucleotide Accession Number

NM_007372

Peptide Sequence

PLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYM

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