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DHX8 Antibody - N-terminal region : Biotin (ARP36380_P050-Biotin)

Product Specifications

Gene Name

DEAH (Asp-Glu-Ala-His) box polypeptide 8

Gene Aliases

DDX8, Dhr2, HRH1, PRP22, PRPF22

Gene ID

1659

Swiss Prot

Q14562

Accession Number

NP_004932

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human DHX8

Target

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is highly homologous to yeast Prp22. This protein facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.

Partner Proteins

NUDCD1; UBC; LIN28A; XRN2; SRPK2; SRPK1; BAG3; PRPF38A; NKAP; ISY1; PRPF40A; ZCCHC10; RBMX2; SAP30BP; CHERP; RBM7; THOC1; MFAP1; DHX8; NOTCH1; KANSL1; PHF5A; MYPN; POLR1B; CRNKL1; TAF9; SMAD3; SMAD2; CAND1; CUL3; SIRT7; USP12

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

DHX8 is supported by BioGPS gene expression data to be expressed in HT1080

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 88%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

139kDa

Shipping Conditions

Wet Ice

Protein Length

1220

NCBI Gene Symbol

DHX8

NCBI GB Accession Number

DHX8

Host or Source

Rabbit

Protein Name

ATP-dependent RNA helicase DHX8

Nucleotide Accession Number

NM_004941

Peptide Sequence

VKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP

Frequently Asked Questions

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