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DDX23 Antibody - C-terminal region : HRP (ARP36376_T100-HRP)

Selected Variant

ARP36376_T100-HRP

Size: 100 µL

Product Specifications

Gene Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

Gene Aliases

Prp28, PRPF28, U5-100K, SNRNP100, U5-100KD

Gene ID

9416

Swiss Prot

Q9BUQ8

Accession Number

NP_004809

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human DDX23

Target

DDX23 encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined.

Partner Proteins

SUMO2; STAU1; UBC; RPA3; RPA2; RPA1; ERG; SUZ12; WBP4; PRPF4B; PAXIP1; PHF5A; SF3A3; SART1; THOC5; PURA; RNU6ATAC; RNU4ATAC; TERF2IP; TERF1; SIRT7; HNRNPA1; SF3A2; SUMO1; Prpf8; TOP1; SNW1; TP63; TP73; MEPCE; USP39; PRPF4; OTUB1; RNPS1; CD2BP2

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Sample Type

DDX23 is strongly supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

90kDa

References & Citations

Teigelkamp, S., et al., (1997) RNA 3 (11), 1313-1326

Shipping Conditions

Wet Ice

Protein Length

820

NCBI Gene Symbol

DDX23

NCBI GB Accession Number

DDX23

Host or Source

Rabbit

Protein Name

Probable ATP-dependent RNA helicase DDX23

Nucleotide Accession Number

NM_004818

Peptide Sequence

EDSAVFYELKQAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA

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