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L3MBTL Antibody - N-terminal region : HRP (ARP35895_P050-HRP)

Selected Variant

ARP35895_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

L (3) mbt-like 1 (Drosophila)

Gene Aliases

L3MBTL, ZC2HC3, H-L (3) MBT, dJ138B7.3

Gene ID

26013

Swiss Prot

Q9Y468

Accession Number

NP_056293

Host

Rabbit

Reactivity

Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human L3MBTL

Target

L3MBTL is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells.This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Partner Proteins

VCP; UBC; PCNA; MCM7; MCM6; MCM5; MCM4; MCM3; CDC45; MCM2; SETD8; TP53; HIST1H1E; L3MBTL1; ETV7; ETV6; HIST2H4A; CBX3; RB1; HIST1H1B; SETD7; CBX5

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

There is BioGPS gene expression data showing that L3MBTL1 is expressed in HEK293T

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Rabbit: 79%; Rat: 93%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

86kDa

References & Citations

Min, J., (2007) Nat. Struct. Mol. Biol. 14 (12), 1229-1230

Shipping Conditions

Wet Ice

Protein Length

772

NCBI Gene Symbol

L3MBTL1

NCBI GB Accession Number

L3MBTL1

Host or Source

Rabbit

Protein Name

Lethal (3) malignant brain tumor-like protein 1

Nucleotide Accession Number

NM_015478

Peptide Sequence

LLKPMKKRKRREYQSPSEEESEPEAMEKQEEGKDPEGQPTASTPESEEWS

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