CBL Antibody: Biotin (ARP35761_P050-Biotin)

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

ERBB4; EGFR; SIRT2; FRS3; PRPSAP2; YWHAH; YWHAE; GRB2; CAPZA1; SH3KBP1; CD2AP; UBC; NEDD8; SUMO1; EPHA2; CRK; ERBB2; NCK2; NCK1; UBE2D2; PIK3R1; LOX; YWHAB; FLT3; IRF1; MYO1C; TNS4; WAS; UBE2D3; PTEN; EPHB1; CTNNB1; CRKL; CBL; STAT5A; SRC; SHC1; RET; ITGA

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.