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PITX2 Antibody - N-terminal region : Biotin (ARP35634_T100-Biotin)

Selected Variant

ARP35634_T100-Biotin

Size: 100 µL

Product Specifications

Gene Name

Paired-like homeodomain 2

Gene Aliases

RS, RGS, ARP1, Brx1, IDG2, IGDS, IHG2, PTX2, RIEG, ASGD4, IGDS2, IRID2, Otlx2, RIEG1

Gene ID

5308

Swiss Prot

Q99697-2

Accession Number

NP_000316

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human PITX2

Target

The PITX2 gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. Mutations in PITX2 are associated with Axenfeld-Rieger syndrome (ARS), iridogoniodysgenesis syndrome (IGDS), and sporadic cases of Peters anomaly. This protein is involved in the development of the eye, tooth and abdominal organs. It also acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.

Partner Proteins

LEF1; Hoxa1; WDR5; SMAD3; HDAC1; CTNNB1; ZNHIT3; TRIM25; HERC5; PDLIM1; PITX2; PROP1; KAT5; Pou1f1; MSX2

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

36kDa

References & Citations

Martin, D.M., et al., (2004) Dev. Biol. 267 (1), 93-108

Shipping Conditions

Wet Ice

Protein Length

324

NCBI Gene Symbol

PITX2

NCBI GB Accession Number

PITX2

Host or Source

Rabbit

Protein Name

Pituitary homeobox 2

Nucleotide Accession Number

NM_000325

Peptide Sequence

SAVSSSSCHHPQPLAMASVLAPGQPRSLDSSKHRLEVHTISDTSSPEAAE

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