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GABRG2 Antibody - C-terminal region : Biotin (ARP35574_T100-Biotin)

Product Specifications

Gene Name

Gamma-aminobutyric acid (GABA) A receptor, gamma 2

Gene Aliases

CAE2, ECA2, FEB8, DEE74, EIEE74, GEFSP3

Gene ID

2566

Swiss Prot

P18507

Accession Number

NP_944493

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human GABRG2

Target

Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA (A) subunits. GABRG2 is the gamma 2 subunit of GABA (A) receptor. Mutations in this gene have been associated with epilepsy and febrile seizures.Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA (A) subunits. This gene encodes the gamma 2 subunit of GABA (A) receptor. Mutations in this gene have been associated with epilepsy and febrile seizures. Alternative splicing of this gene results in transcript variants encoding different isoforms.

Partner Proteins

ZDHHC3; GABARAP; PRKCB; PRKCA; GABRG2; DRD5; PPP3CA

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

36kDa

References & Citations

Sancar, F. (2004) J. Biol. Chem. 279 (45), 47034-47039

Shipping Conditions

Wet Ice

Protein Length

327

NCBI Gene Symbol

GABRG2

NCBI GB Accession Number

GABRG2

Host or Source

Rabbit

Protein Name

Gamma-aminobutyric acid receptor subunit gamma-2

Nucleotide Accession Number

NM_198903

Peptide Sequence

AMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPAPTIDIR

Subunit

Gamma-2

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