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KCNH6 Antibody - middle region : Biotin (ARP35481_P050-Biotin)

Product Specifications

Gene Name

Potassium voltage-gated channel, subfamily H (eag-related), member 6

Gene Aliases

ERG2, ERG-2, HERG2, Kv11.2, hERG-2

Gene ID

81033

Swiss Prot

Q9H252-2

Accession Number

NP_775115

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human KCNH6

Target

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KCNH6 encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

KCNH6 is strongly supported by BioGPS gene expression data to be expressed in NCI-H226

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 85%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 86%; Rabbit: 93%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

100kDa

References & Citations

Gutman, G.A., (2005) Pharmacol. Rev. 57 (4), 473-508

Shipping Conditions

Wet Ice

Protein Length

905

NCBI Gene Symbol

KCNH6

NCBI GB Accession Number

KCNH6

Host or Source

Rabbit

Protein Name

Potassium voltage-gated channel subfamily H member 6

Nucleotide Accession Number

NM_173092

Peptide Sequence

PLASPLHPLEVQGLICGPCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWG

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