Corynoxine B

Corynoxine B is an alkaloid-based autophagy inducer and α-synuclein aggregation inhibitor that ameliorates Mn-induced dysregulation of autophagy and enhances α-synuclein (α-syn) clearance in Parkinson's disease mice[1][2][3][4].

Product Specifications

CAS Number

[17391-18-3]

UNSPSC

12352005

Hazard Statement

H300

Target

α-synuclein

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Corynoxine-B.html

Purity

99.76

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C(NC1=C2C=CC=C1)[C@]32[C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@H](CC)C4)([H])N4CC3

Molecular Formula

C22H28N2O4

Molecular Weight

384.47

Precautions

H300

References & Citations

[1]Yan D, et al. Corynoxine B ameliorates HMGB1-dependent autophagy dysfunction during manganese exposure in SH-SY5Y human neuroblastoma cells. Food Chem Toxicol. 2019 Feb;124:336-348.|[2]Song JX, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014 Jan;10 (1) :144-54. doi: 10.4161/auto.26751. Epub 2013 Jan 1. Erratum in: Autophagy. 2015;11 (9) :1708.|[3]Zhu Q, et al. Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease. Acta Pharm Sin B. 2023 Jun;13 (6) :2701-2714.|[4]Chen L, et al. Corynoxine Protects Dopaminergic Neurons Through Inducing Autophagy and Diminishing Neuroinflammation in Rotenone-Induced Animal Models of Parkinson's Disease. Front Pharmacol. 2021 Apr 13;12:642900.