KCNQ2 Antibody - middle region: FITC (ARP35459_T100-FITC)
Product Specifications
Gene Name
Potassium voltage-gated channel, KQT-like subfamily, member 2
Gene Aliases
EBN, BFNC, DEE7, EBN1, ENB1, HNSPC, KV7.2, KCNA11
Gene ID
3785
Swiss Prot
Q5VYU0
Accession Number
NP_742107
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human KCNQ2
Target
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by the KCNQ2 gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1) .
Partner Proteins
ARIH2; KCNQ3; PRKCA; CALM3; CALM1; CALM2; KCNQ1
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
IHC, WB
Concentration
0.5 mg/mL
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 93%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
43kDa
Shipping Conditions
Wet Ice
Protein Length
393
NCBI Gene Symbol
KCNQ2
Nucleotide Accession Number
NM_172109
Curated Selection
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