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KCNQ2 Antibody - middle region : FITC (ARP35459_T100-FITC)

Selected Variant

ARP35459_T100-FITC

Size: 100 µL

Product Specifications

Gene Name

Potassium voltage-gated channel, KQT-like subfamily, member 2

Gene Aliases

EBN, BFNC, DEE7, EBN1, ENB1, HNSPC, KV7.2, KCNA11

Gene ID

3785

Swiss Prot

Q5VYU0

Accession Number

NP_742107

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human KCNQ2

Target

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by the KCNQ2 gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1) .

Partner Proteins

ARIH2; KCNQ3; PRKCA; CALM3; CALM1; CALM2; KCNQ1

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

IHC, WB

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

43kDa

References & Citations

Tang, B., et al., (2004) J. Neurol. Sci. 221 (1-2), 31-34

Shipping Conditions

Wet Ice

Protein Length

393

NCBI Gene Symbol

KCNQ2

NCBI GB Accession Number

KCNQ2

Host or Source

Rabbit

Nucleotide Accession Number

NM_172109

Peptide Sequence

GNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYI

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