CHRNA7 Antibody - middle region : Biotin (ARP35418_T100-Biotin)

Product Specifications

Gene Name

Cholinergic receptor, nicotinic, alpha 7 (neuronal)

Gene Aliases

NACHRA7, CHRNA7-2

Gene ID

1139

Swiss Prot

P36544

Accession Number

NP_000737

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human CHRNA7

Target

The protein encoded by CHRNA7 displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia.

Partner Proteins

ATXN1; ADCY6; PIK3R1; APP; FYN

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Sample Type

CHRNA7 is supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 92%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

56kDa

References & Citations

Avramopoulou, V., et al., (2004) J. Biol. Chem. 279 (37), 38287-38293

Shipping Conditions

Wet Ice

Protein Length

502

NCBI Gene Symbol

CHRNA7

NCBI GB Accession Number

CHRNA7

Host or Source

Rabbit

Protein Name

Neuronal acetylcholine receptor subunit alpha-7

Nucleotide Accession Number

NM_000746

Peptide Sequence

VPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRF

Subunit

Alpha-7

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