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KCNJ4 Antibody - middle region : FITC (ARP35167_P050-FITC)

Product Specifications

Gene Name

Potassium inwardly-rectifying channel, subfamily J, member 4

Gene Aliases

HIR, HRK1, IRK3, HIRK2, IRK-3, Kir2.3

Gene ID

3761

Swiss Prot

P48050

Accession Number

NP_004972

Host

Rabbit

Reactivity

Human, Mouse, Rat, Dog, Guinea Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human KCNJ4

Target

KCNJ4 is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have??een found for this gene. Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neuronsSeveral different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene.

Partner Proteins

SNTA1; LIN7B; GNGT2; DLG2; IL16; DLG4; DLG1; KCNJ2; CASK; PRKCD; LIN7C; LIN7A; DMD

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

KCNJ4 is supported by BioGPS gene expression data to be expressed in HEK293T

Concentration

0.5 mg/ml

Homology

Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

49kDa

References & Citations

Ji, W., (2008) Nat. Genet. 40 (5), 592-599

Shipping Conditions

Wet Ice

Protein Length

445

NCBI Gene Symbol

KCNJ4

NCBI GB Accession Number

KCNJ4

Host or Source

Rabbit

Protein Name

Inward rectifier potassium channel 4

Nucleotide Accession Number

NM_004981

Peptide Sequence

AVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI

Frequently Asked Questions

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