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ACCN3 Antibody - N-terminal region : Biotin (ARP35152_T100-Biotin)

Selected Variant

ARP35152_T100-Biotin

Size: 100 µL

Product Specifications

Gene Name

Acid-sensing (proton-gated) ion channel 3

Gene Aliases

ACCN3, TNaC1, DRASIC, SLNAC1

Gene ID

9311

Swiss Prot

Q9UHC3

Accession Number

NP_004760

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human ACCN3

Target

ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium.

Partner Proteins

ASIC3; LIN7B; GOPC; INADL; DLG4; MAGI1; ASIC2; STOM; CSNK2A1; PRKACA; STOML1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Concentration

0.5 mg/ml

Homology

Cow: 80%; Dog: 80%; Guinea Pig: 80%; Horse: 80%; Human: 100%; Mouse: 87%; Pig: 87%; Rabbit: 87%; Rat: 87%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

58kDa

References & Citations

Jones, N.G., et al., (2004) J. Neurosci. 24 (48), 10974-9

Shipping Conditions

Wet Ice

Protein Length

531

NCBI Gene Symbol

ASIC3

NCBI GB Accession Number

ASIC3

Host or Source

Rabbit

Protein Name

Acid-sensing ion channel 3

Nucleotide Accession Number

NM_004769

Peptide Sequence

VATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRL

Price

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