TRPC6 Antibody - middle region : Biotin (ARP35144_P050-Biotin)

Product Specifications

Gene Name

Transient receptor potential cation channel, subfamily C, member 6

Gene Aliases

TRP6, FSGS2

Gene ID

7225

Swiss Prot

Q9Y210

Accession Number

NP_004612

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Yeast

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human TRPC6

Target

TRPC6 forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2) .

Partner Proteins

RNF24; TRPC3; ORAI1; TRPM2; TRPC6; SRC; ITPR3; MX1; FYN; TRPC7; TRPC5; TRPC4; TRPC1; TRPC2; ITPR1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 92%; Dog: 92%; Guinea Pig: 92%; Horse: 92%; Human: 100%; Mouse: 85%; Pig: 100%; Rat: 77%; Yeast: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

106kDa

References & Citations

Liu, D., (2008) Arterioscler. Thromb. Vasc. Biol. 28 (4), 746-751

Shipping Conditions

Wet Ice

Protein Length

931

NCBI Gene Symbol

TRPC6

NCBI GB Accession Number

TRPC6

Host or Source

Rabbit

Protein Name

Short transient receptor potential channel 6

Nucleotide Accession Number

NM_004621

Peptide Sequence

KKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSE

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