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SCN1B Antibody - middle region : Biotin (ARP35028_P050-Biotin)

Product Specifications

Gene Name

Sodium channel, voltage-gated, type I, beta subunit

Gene Aliases

DEE52, ATFB13, BRGDA5, EIEE52, GEFSP1

Gene ID

6324

Swiss Prot

Q07699

Accession Number

NP_001028

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human SCN1B

Target

Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics.Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics.[supplied by OMIM].

Partner Proteins

NFASC; SCN2B; ANK3; CNTN1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

25kDa

References & Citations

Selmer, K.K., (2008) Acta Neurol. Scand. 117 (4), 289-292

Shipping Conditions

Wet Ice

Protein Length

218

NCBI Gene Symbol

SCN1B

NCBI GB Accession Number

SCN1B

Host or Source

Rabbit

Protein Name

Sodium channel subunit beta-1

Nucleotide Accession Number

NM_001037

Peptide Sequence

NVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVS

Subunit

Beta-1

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