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SRY Antibody - middle region : HRP (ARP34794_P050-HRP)

Product Specifications

Gene Name

Sex determining region Y

Gene Aliases

TDF, TDY, SRXX1, SRXY1

Gene ID

6736

Swiss Prot

Q05066

Accession Number

NP_003131

Host

Rabbit

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human SRY

Target

SRY is an intronless gene that encodes for a transcription factor, which is a member of the high mobility group (HMG) -box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome) ; translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG) -box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome) ; translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

Olig2; Utf1; Tcf12; Sp1; Pou3f3; Pax3; Jun; Hhex; Egr2; Dlx5; Cebpa; WDR5; SMAD3; HDAC3; KPNB1; EP300; Xpo4; ZNF208; SLC9A3R2; AR

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

SRY is supported by BioGPS gene expression data to be expressed in 721_B

Concentration

0.5 mg/ml

Homology

Human: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

24kDa

References & Citations

Queralt, R., (2008) Am. J. Med. Genet. A 146A (10), 1335-1340

Shipping Conditions

Wet Ice

Protein Length

204

NCBI Gene Symbol

SRY

NCBI GB Accession Number

SRY

Host or Source

Rabbit

Protein Name

Sex-determining region Y protein

Nucleotide Accession Number

NM_003140

Peptide Sequence

SEVQLDNRLYRDDCTKATHSRMEHQLGHLPPINAASSPQQRDRYSHWTKL

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