NFX1 Antibody - N-terminal region : Biotin (ARP34770_P050-Biotin)

NFX1 binds to the X-box motif of MHC class II genes and represses their expression. NFX1 may play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. NFX1 mediates E2-dependent ubiquitination.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.

UBC; BMI1; HECW2; SRSF4; SRSF3; RPS19; RPS3A; RPL22; RPL17; RPL13; RPL7A; RPL6; RPL3; PABPC3; YBX1; NCL; HNRNPM; HSPA1A; HNRNPU; HNRNPH1; HNRNPA2B1; HIST1H2AE; EEF1A2; DMD; DDX5; FAM208B; PABPC1; RPL13A; LARP1; APC2; MATR3; HIST1H4E; USP9X; SIN3A; MAML3

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.