CBX3 Antibody - middle region: FITC (ARP34721_T100-FITC)
Product Specifications
Gene Name
Chromobox homolog 3
Gene Aliases
HECH, HP1-GAMMA, HP1Hs-gamma
Gene ID
11335
Swiss Prot
Q13185
Accession Number
NP_057671
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human CBX3
Target
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. CBX3 binds DNA and is a component of heterochromatin. CBX3 also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of CBX3 may explain the association of heterochromatin with the inner nuclear membrane.At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
Partner Proteins
UBC; SUMO1; MDM2; EED; SUZ12; RNF2; WDR1; DCK; ADSS; THOP1; TALDO1; PTMS; OXCT1; IDH1; HSPE1; HECW2; PARK2; VHL; CHAF1A; AURKB; AURKA; EHMT2; FN1; TRIM39; HNF1A; CBX5; MDC1; TP53BP1; YWHAE; TNKS1BP1; H2AFY; ATXN7L2; CACNB4; BAHD1; CUL1; PCGF6; SIRT7; RYBP
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
IHC, WB
Sample Type
CBX3 is strongly supported by BioGPS gene expression data to be expressed in Jurkat
Concentration
0.5 mg/mL
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
21kDa
Shipping Conditions
Wet Ice
Protein Length
183
NCBI Gene Symbol
CBX3
Protein Name
Chromobox protein homolog 3
Nucleotide Accession Number
NM_016587
Curated Selection
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