CAND1 Antibody - middle region : Biotin (ARP34584_P050-Biotin)

Product Specifications

Gene Name

Cullin-associated and neddylation-dissociated 1

Gene Aliases

TIP120, TIP120A

Gene ID

55832

Swiss Prot

Q86VP6

Accession Number

NP_060918

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human CAND1

Target

CAND1 enhances transcription from various types of promoters. It is a regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. CAND1 prevents neddylation of CUL1 by physically blocking access to the neddylation site. CAND1 disrupts interactions between CUL1 and SKP1A and between CUL1 and F-box proteins.

Partner Proteins

ISG15; SUMO2; SUMO3; UBE2D1; UBC; UBE2M; CUL1; ASB2; ASB1; PPM1G; PAWR; OSBP; KARS; GARS; CARS; APEH; STAT1; SHMT2; IPO7; SEC23A; JMJD6; HSPA4; TRMT112; ZYX; DCUN1D5; DCUN1D1; SRPK2; UBD; FBXL3; FN1; CFTR; vif; CA9; ECT2; NOTCH1; CUL4A; CUL5; RBX1; ERCC6

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.