CAND1 Antibody - middle region : FITC (ARP34584_P050-FITC)
Product Specifications
Gene Name
Cullin-associated and neddylation-dissociated 1
Gene Aliases
TIP120, TIP120A
Gene ID
55832
Swiss Prot
Q86VP6
Accession Number
NP_060918
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human CAND1
Target
CAND1 enhances transcription from various types of promoters. It is a regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. CAND1 prevents neddylation of CUL1 by physically blocking access to the neddylation site. CAND1 disrupts interactions between CUL1 and SKP1A and between CUL1 and F-box proteins.
Partner Proteins
ISG15; SUMO2; SUMO3; UBE2D1; UBC; UBE2M; CUL1; ASB2; ASB1; PPM1G; PAWR; OSBP; KARS; GARS; CARS; APEH; STAT1; SHMT2; IPO7; SEC23A; JMJD6; HSPA4; TRMT112; ZYX; DCUN1D5; DCUN1D1; SRPK2; UBD; FBXL3; FN1; CFTR; vif; CA9; ECT2; NOTCH1; CUL4A; CUL5; RBX1; ERCC6
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
136kDa
References & Citations
Min, K.W., (2005) Biochem. Biophys. Res. Commun. 334 (3), 867-874
Shipping Conditions
Wet Ice
Protein Length
1230
NCBI Gene Symbol
CAND1
NCBI GB Accession Number
CAND1
Host or Source
Rabbit
Protein Name
Cullin-associated NEDD8-dissociated protein 1
Nucleotide Accession Number
NM_018448
Peptide Sequence
AALLTIPEAEKSPLMSEFQSQISSNPELAAIFESIQKDSSSTNLESMDTS
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