LIN28 Antibody - N-terminal region : Biotin (ARP34477_P050-Biotin)
Product Specifications
Gene Name
Lin-28 homolog A (C. elegans)
Gene Aliases
CSDD1, LIN28, LIN-28, ZCCHC1, lin-28A
Gene ID
79727
Swiss Prot
Q9H9Z2
Accession Number
NP_078950
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Pig, Rabbit, Sheep, Yeast
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human LIN28
Target
LIN28 acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. The association of LIN28 with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. IT binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. LIN28 is Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression.
Partner Proteins
HNRNPUL2; HNRNPA3; DHX36; SREK1; TRIM71; LARP4; TGS1; DHX57; GADD45GIP1; LTV1; NOA1; DDX50; KRI1; NOL6; METTL17; NOC3L; ZC3HAV1; PPAN; CCBL2; MEPCE; TSR1; NHP2; NOP10; STRBP; BRIX1; RBM28; PHAX; SRRT; LARP7; DDX41; HP1BP3; NOB1; PRPF19; ZBTB11; SND1; AATF
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
IHC, WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Goat: 91%; Guinea Pig: 86%; Human: 100%; Mouse: 90%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Yeast: 77%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
23kDa
References & Citations
Gregory, S.G., (2006) Nature 441 (7091), 315-321
Shipping Conditions
Wet Ice
Protein Length
209
NCBI Gene Symbol
LIN28A
NCBI GB Accession Number
LIN28A
Host or Source
Rabbit
Protein Name
Protein lin-28 homolog A
Nucleotide Accession Number
NM_024674
Peptide Sequence
GSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLHGAGICKWFNVRM
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