TFB2M Antibody - N-terminal region : FITC (ARP34471_T100-FITC)
Selected Variant
ARP34471_T100-FITC
Size: 100 µL
Product Specifications
Gene Name
Transcription factor B2, mitochondrial
Gene Aliases
Hkp1, mtTFB2
Gene ID
64216
Swiss Prot
Q9H5Q4
Accession Number
NP_071761
Host
Rabbit
Reactivity
Human, Rat, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human TFB2M
Target
TFB2M is a S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. It is also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. It stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.
Partner Proteins
UBC; FBXO6; C1QBP; CUL3; TFB2M; POLRMT; TFAM; PNP
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
IHC, WB
Concentration
0.5 mg/ml
Homology
Horse: 100%; Human: 100%; Rabbit: 83%; Rat: 85%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
45kDa
References & Citations
Falkenberg, M., (2002) Nat. Genet. 31 (3), 289-294
Shipping Conditions
Wet Ice
Protein Length
396
NCBI Gene Symbol
TFB2M
NCBI GB Accession Number
TFB2M
Host or Source
Rabbit
Protein Name
Dimethyladenosine transferase 2, mitochondrial
Nucleotide Accession Number
NM_022366
Peptide Sequence
ECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCD
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