TRIM24 Antibody - middle region : Biotin (ARP34449_P050-Biotin)

Product Specifications

Gene Name

Tripartite motif containing 24

Gene Aliases

PTC6, TF1A, TIF1, RNF82, TIF1A, hTIF1, TIF1ALPHA

Gene ID

8805

Swiss Prot

O15164

Accession Number

NP_056989

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human TRIM24

Target

The exact function of TRIM24 remains unknown. The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Partner Proteins

UBC; SUMO2; SUMO3; TRIM33; TP53; SUMO1; RNF2; RNF181; RNF141; ESR2; BRCA1; SF3B1; SF3B2; SNRPA; NONO; CDK12; NCOA1; TRIM8; NR3C2; ESR1; HIST1H3E; HIST2H4B; HIST4H4; HIST1H3F; HIST2H4A; HIST1H4L; HIST1H4E; HIST1H4B; HIST1H4H; HIST1H4C; HIST1H4J; HIST1H4K

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

TRIM24 is supported by BioGPS gene expression data to be expressed in HeLa

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 82%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.