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APG4B Antibody - C-terminal region : HRP (ARP34434_P050-HRP)

Selected Variant

ARP34434_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

ATG4 autophagy related 4 homolog B (S. cerevisiae)

Gene Aliases

APG4B, AUTL1

Gene ID

23192

Swiss Prot

Q9Y4P1

Accession Number

NP_037457

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human APG4B

Target

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. APG4B encodes a member of the autophagin protein family and is also designated as a member of the C-54 family of cysteine proteases.

Partner Proteins

SUMO2; MAP1LC3B; MAP1LC3A; BAG3; ATG8; YWHAB; GABARAPL1; SQSTM1; UBC; GABARAPL2; ATG10; ATG3; AMBRA1; GABARAP; CAMKK2; ATG12; ULK1; STK3; KRT4; ANXA1; FBXW11; LINC00341

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

ATG4B is strongly supported by BioGPS gene expression data to be expressed in Raji

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

44kDa

References & Citations

Tanida, I., et al., (2004) J. Biol. Chem. 279 (35), 36268-36276

Shipping Conditions

Wet Ice

Protein Length

393

NCBI Gene Symbol

ATG4B

NCBI GB Accession Number

ATG4B

Host or Source

Rabbit

Protein Name

Cysteine protease ATG4B

Nucleotide Accession Number

NM_013325

Peptide Sequence

LGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEIL

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