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CBX1 Antibody - middle region : FITC (ARP34427_T100-FITC)

Selected Variant

ARP34427_T100-FITC

Size: 100 µL

Product Specifications

Gene Name

Chromobox homolog 1

Gene Aliases

CBX, M31, MOD1, p25beta, HP1-BETA, HP1Hsbeta, HP1Hs-beta

Gene ID

10951

Swiss Prot

P83916

Accession Number

NP_006798

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human CBX1

Target

CBX1 is the component of heterochromatin. CBX1 recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. CBX1 interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.Heterochromatin protein-1 (HP1) is localized at heterochromatin sites, where it mediates gene silencing.[supplied by OMIM].

Partner Proteins

PRDM6; SUMO1; UBC; RNF2; PARK2; NR2F6; VHL; EHMT2; ABI3BP; VTN; TRIM39; CBX5; HIST1H3B; KLF11; HIST3H3; PCNA; MECP2; ADNP; POGZ; ADNP2; CBX3; TRIM28; CHAF1A; HIST1H4F; XRCC6; CHD4; H2AFB1; NSL1; SUMO2; HIST1H3A; Mad2l2; Cbx1; DNMT3B; ZNF382; H3F3A; SUV420

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

21kDa

References & Citations

Verschure, P.J., et al., (2005) Mol. Cell. Biol. 25 (11), 4552-4564

Shipping Conditions

Wet Ice

Protein Length

185

NCBI Gene Symbol

CBX1

NCBI GB Accession Number

CBX1

Host or Source

Rabbit

Protein Name

Chromobox protein homolog 1

Nucleotide Accession Number

NM_006807

Peptide Sequence

PDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKP

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