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AFDN Antibody - N-terminal region : HRP (ARP34225_T100-HRP)

Selected Variant

ARP34225_T100-HRP

Size: 100 µL

Product Specifications

Gene Name

Afadin, adherens junction formation factor

Gene Aliases

AF6, MLLT4, MLL-AF6, l-afadin

Gene ID

4301

Swiss Prot

P55196

Accession Number

EAW47480

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human MLLT4

Target

This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t (6;11) (q27; q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.

Partner Proteins

UBC; LGR4; LATS2; YWHAQ; YWHAE; VCAM1; SMAD2; ITGA4; GRB2; FN1; SIRT7; HNRNPA1; ARRB2; YWHAG; YWHAB; KMT2A; MEN1; PVRL4; PICK1; RIT2; SORBS2; F11R; NRXN2; SSX2IP; RIT1; NRXN3; PVRL3; PVRL1; MRAS; SORBS1; EPHB6; EPHA7; JAG1; EPHB3; RALGDS; TJP1; EPHB2; PVR

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Sample Type

MLLT4 is strongly supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 85%; Rat: 100%; Yeast: 92%; Zebrafish: 91%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

74kDa

Shipping Conditions

Wet Ice

Protein Length

674

NCBI Gene Symbol

AFDN

NCBI GB Accession Number

AFDN

Host or Source

Rabbit

Protein Name

Afadin

Nucleotide Accession Number

NM_001040000

Peptide Sequence

GVIQNFKRTLSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAE

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