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CRSP6 Antibody - N-terminal region : Biotin (ARP34192_P050-Biotin)

Product Specifications

Gene Name

Mediator complex subunit 17

Gene Aliases

SRB4, CRSP6, CRSP77, DRIP80, TRAP80

Gene ID

9440

Swiss Prot

Q9NVC6

Accession Number

NP_004259

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human CRSP6

Target

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by CRSP6 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor- (TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.

Partner Proteins

UBC; BRCA1; CDK19; CDK8; MED26; POLR2C; ESR2; MED19; FBXW7; EPAS1; TFIP11; MED24; MED21; MED14; MED11; MED28; WDR33; CPSF2; UBD; BCL6; SMARCA4; SUZ12; MED10; CTDP1; SREBF1; MED25; MED15; TRA; MED1; OBFC1; MED18; ZC3H13; MED12; QKI; TRIP4; TADA2A; SUPT7L

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB, CHIP

Purification

Affinity Purified

Sample Type

MED17 is supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

73kDa

References & Citations

Wang, Q., et al., (2002) J. Biol. Chem. 277 (45), 42852-42858

Shipping Conditions

Wet Ice

Product Datasheet

Anti-MED17 (ARP34192_P050-Biotin) antibody

Protein Length

651

NCBI Gene Symbol

MED17

NCBI GB Accession Number

MED17

Host or Source

Rabbit

Protein Name

Mediator of RNA polymerase II transcription subunit 17

Nucleotide Accession Number

NM_004268

Peptide Sequence

AAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILG

Subunit

17

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