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XRCC5 Antibody - C-terminal region : FITC (ARP34121_T100-FITC)

Product Specifications

Gene Name

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

Gene Aliases

KU80, KUB2, Ku86, NFIV, KARP1, KARP-1

Gene ID

7520

Swiss Prot

Q4VBQ5

Accession Number

NP_066964

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human XRCC5

Target

XRCC5 encodes the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V (D) J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V (D) J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Partner Proteins

HUWE1; UBC; EHF; ELF3; SUMO2; SUMO3; BRCA1; ATRX; Fbxl16; NEDD8; SUMO1; MDM2; RPA3; RPA2; RPA1; SUZ12; EED; RNF2; BMI1; EIF4B; C1QBP; RPL24; PLCB3; PRMT3; EIF3J; CUL2; CSDE1; SF1; TRMT1; SAMHD1; DNMBP; GANAB; HYOU1; NCL; NARS; MSH2; JUP; HSPA4; PARP1; TAR

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Sample Type

XRCC5 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 92%; Dog: 92%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 85%; Rabbit: 93%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

83kDa

References & Citations

Sawchuk, D.J., et al., (2004) J. Biol. Chem. 279 (28), 29821-29831

Shipping Conditions

Wet Ice

Protein Length

732

NCBI Gene Symbol

XRCC5

NCBI GB Accession Number

XRCC5

Host or Source

Rabbit

Protein Name

X-ray repair cross-complementing protein 5

Nucleotide Accession Number

NM_021141

Peptide Sequence

GITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFEEGGDVDDLLDM

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