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G22P1 Antibody - N-terminal region : Biotin (ARP34117_T100-Biotin)

Selected Variant

ARP34117_T100-Biotin

Size: 100 µL

Product Specifications

Gene Name

X-ray repair complementing defective repair in Chinese hamster cells 6

Gene Aliases

ML8, KU70, TLAA, CTC75, CTCBF, G22P1

Gene ID

2547

Swiss Prot

Q6FG89

Accession Number

NP_001460

Host

Rabbit

Reactivity

Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human G22P1

Target

The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V (D) J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.

Partner Proteins

UBC; ELF3; EHF; CHD1L; SUMO2; SUMO3; MDM2; EMD; ATRX; RPA3; RPA2; RPA1; PCNA; EED; PRPF40A; SUPT5H; ST13; SET; PLOD2; PIN1; NARS; MSH2; RPSA; JUP; IMPDH1; MSH6; GART; DPYSL3; CTNNA1; SAMHD1; ATP6V1B2; GANAB; SWAP70; WBP4; HYOU1; FARSB; RANBP3; CUL2; CSDE1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Sample Type

XRCC6 is supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Dog: 93%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 86%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

70kDa

References & Citations

Sawchuk, D.J., et al., (2004) J. Biol. Chem. 279 (28), 29821-29831

Shipping Conditions

Wet Ice

Protein Length

609

NCBI Gene Symbol

XRCC6

NCBI GB Accession Number

XRCC6

Host or Source

Rabbit

Protein Name

X-ray repair cross-complementing protein 6

Nucleotide Accession Number

NM_001469

Peptide Sequence

NFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQDMMGHGSDYSLSEVL

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