ATP7A Antibody - N-terminal region : Biotin (ARP33797_T100-Biotin)
Product Specifications
Gene Name
ATPase, Cu++ transporting, alpha polypeptide
Gene Aliases
MK, MNK, DSMAX, SMAX3
Gene ID
538
Swiss Prot
Q04656
Accession Number
NP_000043
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Horse, Pig, Sheep
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human ATP7A
Target
The ATP7A gene encodes the Menkes copper-translocating P-type ATPase, a ubiquitous protein that regulates the absorption of copper in the gastrointestinal tract. Inside cells, this protein has a dual function: it delivers copper to cuproenzymes in the Golgi compartment and effluxes excess copper. The trafficking mechanism and catalytic activity combine to facilitate absorption and intercellular transport of copper. Menkes disease, a systemic copper deficiency disorder, is caused by mutations in the ATP7A gene.
Partner Proteins
ACIN1; UBC; COMMD1; CLU; ATOX1; PDZD11; CP; GLRX
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Concentration
0.5 mg/ml
Homology
Cow: 93%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Sheep: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
163kDa
References & Citations
Ueta, A., Unpublished
Shipping Conditions
Wet Ice
Specificity
The immunizing peptide used to raise this antibody is 100% homologous to isoform 3 (503aa 54.3kDa), 1 (1514aa, 165kDa), 2 (1581aa, 172kDa) and 5 (1422aa, 154kDa) of human ATP7A.
Protein Length
1500aa
NCBI Gene Symbol
ATP7A
NCBI GB Accession Number
ATP7A
Host or Source
Rabbit
Protein Name
ATP7A protein EMBL BAC82353.1
Nucleotide Accession Number
NM_000052.5
Peptide Sequence
MKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYQ
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