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ATP7A Antibody - N-terminal region : HRP (ARP33797_T100-HRP)

Selected Variant

ARP33797_T100-HRP

Size: 100 µL

Product Specifications

Gene Name

ATPase, Cu++ transporting, alpha polypeptide

Gene Aliases

MK, MNK, DSMAX, SMAX3

Gene ID

538

Swiss Prot

Q04656

Accession Number

NP_000043

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human ATP7A

Target

The ATP7A gene encodes the Menkes copper-translocating P-type ATPase, a ubiquitous protein that regulates the absorption of copper in the gastrointestinal tract. Inside cells, this protein has a dual function: it delivers copper to cuproenzymes in the Golgi compartment and effluxes excess copper. The trafficking mechanism and catalytic activity combine to facilitate absorption and intercellular transport of copper. Menkes disease, a systemic copper deficiency disorder, is caused by mutations in the ATP7A gene.

Partner Proteins

ACIN1; UBC; COMMD1; CLU; ATOX1; PDZD11; CP; GLRX

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Sheep: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

163kDa

References & Citations

Ueta, A., Unpublished

Shipping Conditions

Wet Ice

Specificity

The immunizing peptide used to raise this antibody is 100% homologous to isoform 3 (503aa 54.3kDa), 1 (1514aa, 165kDa), 2 (1581aa, 172kDa) and 5 (1422aa, 154kDa) of human ATP7A.

Protein Length

1500aa

NCBI Gene Symbol

ATP7A

NCBI GB Accession Number

ATP7A

Host or Source

Rabbit

Protein Name

ATP7A protein EMBL BAC82353.1

Nucleotide Accession Number

NM_000052.5

Peptide Sequence

MKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYQ

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