PARP11 Antibody - middle region : FITC (ARP33767_P050-FITC)
Product Specifications
Gene Name
Poly (ADP-ribose) polymerase family, member 11
Gene Aliases
ARTD11, MIB006, C12orf6
Gene ID
57097
Swiss Prot
Q9NR21
Accession Number
NP_065100
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human PARP11
Target
PARP1 encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. PARP1 can be cleaved resulting in fragements of 29 and 85 kDa.
Partner Proteins
MDFI; TRIP13; DCAF11; RNF114; OTUD4; LYZ; GTPBP3; NUP98
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
39kDa
References & Citations
Scherer, S.E., (2006) Nature 440 (7082), 346-351
Shipping Conditions
Wet Ice
Protein Length
331
NCBI Gene Symbol
PARP11
NCBI GB Accession Number
PARP11
Host or Source
Rabbit
Protein Name
Poly [ADP-ribose] polymerase 11
Nucleotide Accession Number
NM_020367
Peptide Sequence
IKHGNTFQIHGVSLQQRHLFRTYKSMFLARVLIGDYINGDSKYMRPPSKD
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